Blar i forfatter "Vigh, Laszlo"

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    • Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells 

      Crul, Tim; Csoboz, Balint; Gombos, Imre; Marton, Annamaria; Peter, Maria; Balogh, Gabor; Vizler, Csaba; Szente, Lajos; Vigh, Laszlo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)
      The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

    • Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury 

      Dukay, Brigitta; Walter, Fruzsina; Vigh, Judit; Barabasi, Beata; Hajdu, Petra; Balassa, Tamas; Migh, Ede; Kincses, Andras; Hoyk, Zsofia; Szogi, Titanilla; Borbely, Emoke; Csoboz, Balint; Horvath, Peter; Fulop, Livia; Penke, Botond; Vigh, Laszlo; Deli, Maria; Santha, Mikos; Toth, Melinda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-10)
      Background - Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its modulatory activity on inflammation, yet its exact role in neuroinflammation is poorly understood. In order to shed light on the exact ...